Prenatal Care
Chromosome number abnormality - 13, 18, 21, X, and Y chromosome
The most common chromosomal abnormalities found in prenatal cases are numerical variations. Autosomal chromosome aneuploid trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome), trisomy 13 (Patau syndrome), and X/Y chromosome number abnomality (Turner syndrome and Klinefelter's Syndrome, etc.) account for 89% of chromosome abnormalities. The consequences of fetal aneuploidy vary from incompatibility with life to intellectual and physical disability. Chromosome number abnormalities usually associated with physical growth delays, intellectual disability, and characteristic facial features.
Product Information
Uses polymerase chain reaction (PCR) to amplify different short tandem repeat (STR) markers located on chromosomes. PCR product is analyzed by high-resolution capillary electrophoresis. The chromosome numbers can be estimated by chromosomal STR markers amplification result.
Features and advantages
Single-Tube Detection
All STRs marker located on 13, 18, 21, X, and Y chromosome can be amplified in one tube
Compliance with guideline
All STRs marker consistent with the ACC/CMGS guideline
High Sensitivity
Low sample requirement
Easy-to-use and Fast
Amplified in one tube Minimize the number of reagents Simplified workflow
Workflow
References
- Donaghue. C, Mann. K, Diack. JSW, et al. (2004). ACC/CMGS best practice guidelines for QF-PCR-based diagnosis of aneuploidy. S57-S57.
- Mann K, Ogilvie CM. QF-PCR: application, overview and review of the literature. Prenat Diagn. 2012;32(4):309‐314.
- Tekcan A, Tural S, Elbistan M, Kara N, Guven D, Kocak I. The combined QF-PCR and cytogenetic approach in prenatal diagnosis. Mol Biol Rep. 2014;41(11):7431‐7436.
