The risk genes refer tendency of genetic factors to influence susceptibility to specific diseases, so it can be analyzed from molecular biology whether there is a risk of suffering from diseases. Through the detection of personal genetic information, early planning and health management can effectively delay or prevent diseases occurred.

Dementia is not a single disease, but a group of symptoms. The symptoms of dementia are not only irreversible memory loss but affect other cognitive functions, including the continuous deterioration of language, spatial sense, calculation, judgment, abstract thinking ability, attention, and other functions. Alzheimer's disease is the most common dementia. More than 95% of patients have late-onset Alzheimer's disease. The age of onset is above 65 years old, and it is affected by genetic and environmental factors. Every three seconds, one more person suffering from dementia. In Taiwan, there is one patient in every five families. According to statistics, about 7.88% of the elderly over 65-year-old are patients.

APOE
‍APOE is apolipoprotein E, involved in the metabolism and deposition of amyloid (Aβ), and it is the most associated risk gene for Alzheimer's disease. APOE is divided into three subtypes ε2, ε3, and ε4. ε2 has a protective effect, and ε4 increases the risk of Alzheimer's disease. A large number of studies have demonstrated that the incidence of suffering Alzheimer's disease will increase by 3-4 times acquired with an ε4, and homozygous genotype (ε4/ε4) will increase by 9-15 times compared to normal.
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TOMM40
‍TOMM40 is one of the channel proteins that constitute Aβ-amyloid into the mitochondria. It can effectively predict who will suffer Alzheimer's disease and help explain why people who carry the most common genotype ε3 will also get Alzheimer's. The length of T-base repeats (poly-T) of TOMM40 and the genotype of APOE can provide compete for information on the risk of Alzheimer's disease and improve the reliability of risk assessment.